Diabetes is a serious disease that in 2014 plagued 422 million individuals in total worldwide, with one in 11 adults affected. The disease is characterized by hyperglycemia due to autoimmune destruction of β-cells in the pancreas (type 1) or insulin resistance, usually due to obesity, with decreased pancreatic insulin production and β-cell failure (type 2). Metabolic disturbances associated with diabetes cause a vast number of complications ranging from cardiovascular and cerebrovascular diseases to neuropathy, retinopathy, nephropathy, and poor wound healing. These complications decrease the quality of life and can lead to death; the most common cause of mortality for diabetic patients is cardiovascular disease.
Current therapies have revolutionized diabetes, no longer making it a death sentence. The therapies target hyperglycemic states, but even when patients have remarkably good glycemic control devastating complications still occur. This is probably because diabetes is a more complicated pathology than we currently understand.
The good news? With the correct treatment and recommended lifestyle changes, many people with diabetes are able to prevent or delay the onset of complications.
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